Lactoferrin-containing immunocomplex mediates antitumor effects by resetting tumor-associated macrophages to M1 phenotype

BACKGROUND: Tumor-associated macrophages (TAMs) resemble M2-polarized cells with potent immunosuppressive activity and play a pivotal role in tumor growth and progression. Converting TAMs to proinflammatory M1-like phenotype is thus an attractive strategy for antitumor immunotherapy. METHODS: A mous...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Dong, Hongliang, Yang, Yueyao, Gao, Chenhui, Sun, Hehe, Wang, Hongmin, Hong, Chao, Wang, Jun, Gong, Fangyuan, Gao, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Basic Tumor Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174070/
https://ncbi.nlm.nih.gov/pubmed/32217759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2019-000339
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