Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

While tuberculosis (TB) is a risk factor in HIV-1-infected individuals, the mechanisms by which Mycobacterium tuberculosis (Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube...

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Pubblicato in:eLife
Autori principali: Dupont, Maeva, Souriant, Shanti, Balboa, Luciana, Vu Manh, Thien-Phong, Pingris, Karine, Rousset, Stella, Cougoule, Céline, Rombouts, Yoann, Poincloux, Renaud, Ben Neji, Myriam, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J, Benet, Susana, Martinez-Picado, Javier, Izquierdo-Useros, Nuria, Sasiain, Maria del Carmen, Maridonneau-Parini, Isabelle, Neyrolles, Olivier, Vérollet, Christel, Lugo-Villarino, Geanncarlo
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7173963/
https://ncbi.nlm.nih.gov/pubmed/32223897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52535
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