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PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi Ev (TcEv) from axenic parasite cultures, and...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Choudhuri, Subhadip, Garg, Nisha Jain
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7173744/
https://ncbi.nlm.nih.gov/pubmed/32315358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008474
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