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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid

The series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and al...

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Publicat a:Eur J Med Chem
Autors principals: Siebert, Agnieszka, Wysocka, Magdalena, Krawczyk, Beata, Cholewiński, Grzegorz, Rachoń, Janusz
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Masson SAS. 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7173178/
https://ncbi.nlm.nih.gov/pubmed/29216563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.11.094
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