MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation

Hepatocyte apoptosis is the main pathophysiological process underlying liver ischemia/reperfusion (I/R) injury. Mitochondrial abnormalities have a vital role in hepatocellular damage. The hepatoprotective effects of mesenchymal stem cells (MSCs) have been previously demonstrated. In this study, we a...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zheng, Jun, Chen, Liang, Lu, Tongyu, Zhang, Yingcai, Sui, Xin, Li, Yang, Huang, Xuna, He, Liying, Cai, Jianye, Zhou, Chaorong, Liang, Jinliang, Chen, Guihua, Yao, Jia, Yang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171190/
https://ncbi.nlm.nih.gov/pubmed/32312955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2424-1
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