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The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens

The striatum is critical for cocaine-induced locomotor responses. Although the role of D1 receptor-expressing neurons is established, underlying molecular pathways are not fully understood. We studied the role of Pyk2, a non-receptor, calcium-dependent protein-tyrosine kinase. The locomotor coordina...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: de Pins, Benoit, Montalban, Enrica, Vanhoutte, Peter, Giralt, Albert, Girault, Jean-Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170924/
https://ncbi.nlm.nih.gov/pubmed/32313025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63426-5
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