Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients

PURPOSE: Tacrolimus is a nephrotoxic immunosuppressant historically monitored via enzyme-based immunoassay (IA). After 2011, the 2 largest laboratory companies in the United States implemented tacrolimus quantification by liquid chromatography–mass spectrometry (LC-MS); this method excludes metaboli...

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Veröffentlicht in:Am J Health Syst Pharm
Hauptverfasser: Kolaitis, Nicholas A, Calabrese, Daniel R, Ahearn, Patrick, Venado, Aida, Florez, Rebecca, Lei, Huey-Ling, Isaak, Karolina, Henricksen, Erik, Martinez, Emily, Chong, Tiffany, Shah, Rupal J, Leard, Lorriana E, Kleinhenz, Mary Ellen, Golden, Jeffrey, De Marco, Teresa, Greenland, John R, Kukreja, Jasleen, Hays, Steven R, Blanc, Paul D, Singer, Jonathan P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Clinical Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170730/
https://ncbi.nlm.nih.gov/pubmed/31696925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajhp/zxz243
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