Is Treatment with Denosumab Associated with Local Recurrence in Patients with Giant Cell Tumor of Bone Treated with Curettage? A Systematic Review

BACKGROUND: Denosumab, a monoclonal antibody that binds to receptor activation of nuclear factor-kappa ß ligand (RANKL), has been used as a drug to treat aggressive giant cell tumors of bone. It is unclear whether preoperative denosumab therapy is associated with the local recurrence risk in patient...

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Bibliographic Details
Published in:Clin Orthop Relat Res
Main Authors: Tsukamoto, Shinji, Tanaka, Yuu, Mavrogenis, Andreas F., Kido, Akira, Kawaguchi, Masahiko, Errani, Costantino
Format: Artigo
Language:Inglês
Published: Wolters Kluwer 2019
Subjects:
Clinical Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170677/
https://ncbi.nlm.nih.gov/pubmed/31794487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CORR.0000000000001074
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