Multistep Metabolic Engineering of Bacillus licheniformis To Improve Pulcherriminic Acid Production

The cyclodipeptide pulcherriminic acid, produced by Bacillus licheniformis, is derived from cyclo(l-Leu–l-Leu) and possesses excellent antibacterial activities. In this study, we achieved the high-level production of pulcherriminic acid via multistep metabolic engineering of B. licheniformis DWc9n*....

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Bibliografiske detaljer
Udgivet i:Appl Environ Microbiol
Main Authors: Wang, Shiyi, Wang, Huan, Zhang, Dan, Li, Xiaoyun, Zhu, Jiang, Zhan, Yangyang, Cai, Dongbo, Wang, Qin, Ma, Xin, Wang, Dong, Chen, Shouwen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Biotechnology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7170474/
https://ncbi.nlm.nih.gov/pubmed/32111589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03041-19
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