D-mannose attenuates bone loss in mice via Treg cell proliferation and gut microbiota-dependent anti-inflammatory effects

BACKGROUND: D-mannose exhibits strong anti-inflammatory properties, but whether it has beneficial effects on preventing and treating osteoporosis remains unknown. METHODS: Female, 12-month-old senile C57BL6/J mice (s-Man group) and 8-week-old ovariectomized C57BL6/J mice (OVX-Man group) were treated...

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Detalhes bibliográficos
Publicado no:Ther Adv Chronic Dis
Main Authors: Liu, Hao, Gu, Ranli, Zhu, Yuan, Lian, Xiaomin, Wang, Siyi, Liu, Xuenan, Ping, Zhang, Liu, Yunsong, Zhou, Yongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169364/
https://ncbi.nlm.nih.gov/pubmed/32341776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2040622320912661
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