First in-human PET study and kinetic evaluation of [(18)F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of cortisone into the stress hormone cortisol. This first-in-human brain imaging study characterizes the kinetic modeling and test–retest reproducibility of [(18)F]AS2471907, a novel PET radiotracer for 11β-HSD1. Eight...

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Pubblicato in:J Cereb Blood Flow Metab
Autori principali: Bhatt, Shivani, Nabulsi, Nabeel B, Li, Songye, Cai, Zhengxin, Matuskey, David, Bini, Jason, Najafzadeh, Soheila, Kapinos, Michael, Ropchan, Jim R, Carson, Richard E, Cosgrove, Kelly P, Huang, Yiyun, Hillmer, Ansel T
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2019
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7168798/
https://ncbi.nlm.nih.gov/pubmed/30895878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19838633
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