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Emerging roles of deubiquitinases in cancer‐associated pathways

Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activati...

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Detalhes bibliográficos
Publicado no:IUBMB Life
Main Authors: Sacco, Joseph J., Coulson, Judy M., Clague, Michael J., Urbé, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., a Wiley company 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165618/
https://ncbi.nlm.nih.gov/pubmed/20073038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/iub.300
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