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Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest

In bacteria, the first two steps of gene expression—transcription and translation—are spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double-stranded breaks and genomic i...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Stevenson-Jones, Flint, Woodgate, Jason, Castro-Roa, Daniel, Zenkin, Nikolay
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165469/
https://ncbi.nlm.nih.gov/pubmed/32238560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919985117
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