A Sox2/miR-486–5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks

Glioblastoma multiforme (GBM) and other solid malignancies are heterogeneous and contain subpopulations of tumor cells that exhibit stem-like features. Our recent findings point to a de-differentiation mechanism by which reprogramming transcription factors Oct4 and Sox2 drive the stem-like phenotype...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Lopez-Bertoni, Hernando, Kotchetkov, Ivan S., Mihelson, Nicole, Lal, Bachchu, Rui, Yuan, Ames, Heather, Lugo-Fagundo, Maria, Guerrero-Cazares, Hugo, Quiñones-Hinojosa, Alfredo, Green, Jordan J., Laterra, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165043/
https://ncbi.nlm.nih.gov/pubmed/32094299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1624
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