LIN9 and NEK2 are core regulators of mitotic fidelity that can be therapeutically targeted to overcome taxane resistance

A significant therapeutic challenge for cancer patients is resistance to chemotherapies such as taxanes. Overexpression of LIN9, a transcriptional regulator of cell cycle progression, occurs in 65% of patients with triple negative breast cancer (TNBC), a disease commonly treated with these drugs. He...

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Udgivet i:Cancer Res
Main Authors: Roberts, Melyssa S., Sahni, Jennifer M., Schrock, Morgan S., Piemonte, Katrina M., Weber-Bonk, Kristen L., Seachrist, Darcie D., Avril, Stefanie, Anstine, Lindsey J., Singh, Salendra, Sizemore, Steven T., Varadan, Vinay, Summers, Matthew K., Keri, Ruth A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165041/
https://ncbi.nlm.nih.gov/pubmed/32054769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3466
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