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Cobalt ion interaction with TMEM16A calcium-activated chloride channel: Inhibition and potentiation

TMEM16A, a Ca(2+)-sensitive Cl(-) channel, plays key roles in many physiological functions related to Cl(-) transport across lipid membranes. Activation of this channel is mediated via binding intracellular Ca(2+) to the channel with a relatively high apparent affinity, roughly in the sub-μM to low...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Nguyen, Dung M., Chen, Louisa S., Jeng, Grace, Yu, Wei-Ping, Chen, Tsung-Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164836/
https://ncbi.nlm.nih.gov/pubmed/32302365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0231812
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