Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is a global health emergency. An attractive drug target among coronaviruses is the main protease (M(pro), also called 3CL(pro)) because of its essential role in processing the poly...

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Vydáno v:Science
Hlavní autoři: Zhang, Linlin, Lin, Daizong, Sun, Xinyuanyuan, Curth, Ute, Drosten, Christian, Sauerhering, Lucie, Becker, Stephan, Rox, Katharina, Hilgenfeld, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164518/
https://ncbi.nlm.nih.gov/pubmed/32198291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abb3405
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