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Mechanopharmacology and Synergistic Relaxation of Airway Smooth Muscle

Asthmatic airways are stiffer than normal. We have shown that the cytoskeletal passive stiffness of airway smooth muscle (ASM) can be regulated by intracellular signaling pathways, especially those associated with Rho kinase (ROCK). We have also shown that an oscillatory strain reduces the passive s...

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Detalhes bibliográficos
Publicado no:J Eng Sci Med Diagn Ther
Main Authors: Wang, Lu, Chitano, Pasquale, Paré, Peter D., Seow, Chun Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Mechanical Engineers 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164492/
https://ncbi.nlm.nih.gov/pubmed/32328573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1115/1.4042477
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