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Mechanopharmacology and Synergistic Relaxation of Airway Smooth Muscle

Asthmatic airways are stiffer than normal. We have shown that the cytoskeletal passive stiffness of airway smooth muscle (ASM) can be regulated by intracellular signaling pathways, especially those associated with Rho kinase (ROCK). We have also shown that an oscillatory strain reduces the passive s...

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Опубликовано в: :J Eng Sci Med Diagn Ther
Главные авторы: Wang, Lu, Chitano, Pasquale, Paré, Peter D., Seow, Chun Y.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Mechanical Engineers 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164492/
https://ncbi.nlm.nih.gov/pubmed/32328573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1115/1.4042477
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