An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Herein, we show that the ribonucleoside analog β-D-N(4)-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antivi...

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Vydáno v:Sci Transl Med
Hlavní autoři: Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7164393/
https://ncbi.nlm.nih.gov/pubmed/32253226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abb5883
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