Activity‐based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights

The reversible post‐translational modification of proteins by ubiquitin and ubiquitin‐like proteins regulates almost all cellular processes, by affecting protein degradation, localization, and complex formation. Deubiquitinases (DUBs) are proteases that remove ubiquitin modifications or cleave ubiqu...

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Bibliographic Details
Published in:FEBS J
Main Authors: Hewings, David S., Flygare, John A., Bogyo, Matthew, Wertz, Ingrid E.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Special Issue: Proteases
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163952/
https://ncbi.nlm.nih.gov/pubmed/28196299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14039
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