Safety, tolerability, pharmacokinetics and pharmacodynamics of parenterally administered dutogliptin: A prospective dose‐escalating trial

AIMS: Animal studies suggest that inhibition of dipeptidyl peptidase 4 (DPP‐IV) may improve heart function and survival after myocardial infarction by increasing cardiac myocytes’ regenerative capacity. Parenterally administered dutogliptin may provide continuous strong DPP‐IV inhibition to translat...

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Publicat a:Br J Clin Pharmacol
Autors principals: Buchtele, Nina, Schwameis, Michael, Schoergenhofer, Christian, Derhaschnig, Ulla, Firbas, Christa, Karch, Rudolf, Nix, Darrell, Schenk, Roman, Jilma, Bernd
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163368/
https://ncbi.nlm.nih.gov/pubmed/31912513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14208
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