Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells

2-methoxyestradiol (2-ME) is a physiological anticancer compound, metabolite of 17β-estradiol. Previously, our group evidenced that from mechanistic point of view one of anticancer mechanisms of action of 2-ME is specific induction and nuclear hijacking of neuronal nitric oxide synthase (nNOS), resu...

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Udgivet i:Redox Biol
Main Authors: Gorska-Ponikowska, Magdalena, Ploska, Agata, Jacewicz, Dagmara, Szkatula, Michal, Barone, Giampaolo, Lo Bosco, Giosuè, Lo Celso, Fabrizio, Dabrowska, Aleksandra M, Kuban-Jankowska, Alicja, Gorzynik-Debicka, Monika, Knap, Narcyz, Chmurzynski, Lech, Dobrucki, Lawrence Wawrzyniec, Kalinowski, Leszek, Wozniak, Michal
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162974/
https://ncbi.nlm.nih.gov/pubmed/32305006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101522
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