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MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer

Chemotherapy is the first-tier treatment regime for gastric cancer (GC) patients at advance stages. Mesenchymal stem cell (MSC) cam affect drug-resistance of GC cells in tumor microenvironment, but the detailed mechanism remains poorly understood. Present study aimed to investigate the regulation of...

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Publicat a:Cell Death Dis
Autors principals: Wu, Honglei, Liu, Bin, Chen, Zhaosheng, Li, Guangchun, Zhang, Zhen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7162922/
https://ncbi.nlm.nih.gov/pubmed/32300102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2426-z
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