Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD(+)/NADH ratios

BACKGROUND AND PURPOSE: Alzheimer's disease (AD) is a multifactorial condition leading to cognitive decline and represents a major global health challenge in ageing populations. The lack of effective AD therapeutics led us to develop multifunctional nicotinoyl hydrazones to target several patho...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Wu, Zhixuan, Palanimuthu, Duraippandi, Braidy, Nady, Salikin, Nor Hawani, Egan, Suhelen, Huang, Michael L.H., Richardson, Des R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161547/
https://ncbi.nlm.nih.gov/pubmed/31895471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14963
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