Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease

Mitochondrial dysfunction has been implicated in multiple neurodegenerative diseases but remains largely unexplored in Creutzfeldt-Jakob disease. Here, we characterize the mitochondrial respiratory chain at the individual neuron level in the MM1 and VV2 common molecular subtypes of sporadic Creutzfe...

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Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Flønes, Irene H., Ricken, Gerda, Klotz, Sigrid, Lang, Alexandra, Ströbel, Thomas, Dölle, Christian, Kovacs, Gabor G., Tzoulis, Charalampos
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160955/
https://ncbi.nlm.nih.gov/pubmed/32299489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00915-8
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