An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

BACKGROUND: Current acute myeloid leukemia (AML) therapy fails to eliminate quiescent leukemic blasts in the bone marrow, leading to about 50% of patient relapse by increasing AML burden in the bone marrow, blood, and extramedullar sites. We developed a protein-based nanoparticle conjugated to the p...

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Bibliografske podrobnosti
izdano v:J Hematol Oncol
Main Authors: Pallarès, Victor, Unzueta, Ugutz, Falgàs, Aïda, Sánchez-García, Laura, Serna, Naroa, Gallardo, Alberto, Morris, Gordon A., Alba-Castellón, Lorena, Álamo, Patricia, Sierra, Jorge, Villaverde, Antonio, Vázquez, Esther, Casanova, Isolda, Mangues, Ramon
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160905/
https://ncbi.nlm.nih.gov/pubmed/32295630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-00863-9
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