Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection

HIV-associated neurocognitive disorders (HAND) affect over half of HIV-infected individuals, despite antiretroviral therapy (ART). Therapeutically targetable mechanisms underlying HAND remain elusive, partly due to a lack of a representative model. We developed a human-induced pluripotent stem cell...

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Publicado en:Stem Cell Reports
Main Authors: Ryan, Sean K., Gonzalez, Michael V., Garifallou, James P., Bennett, Frederick C., Williams, Kimberly S., Sotuyo, Nathaniel P., Mironets, Eugene, Cook, Kieona, Hakonarson, Hakon, Anderson, Stewart A., Jordan-Sciutto, Kelly L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160309/
https://ncbi.nlm.nih.gov/pubmed/32220329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2020.02.010
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