Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

The links between β-amyloid (Aβ) and tau in Alzheimer’s disease are unclear. Cognitively unimpaired persons with signs of Aβ pathology had increased cerebrospinal fluid (CSF) phosphorylated tau (P-tau181 and P-tau217) and total-tau (T-tau), which increased over time, despite no detection of insolubl...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Mattsson-Carlgren, Niklas, Andersson, Emelie, Janelidze, Shorena, Ossenkoppele, Rik, Insel, Philip, Strandberg, Olof, Zetterberg, Henrik, Rosen, Howard J., Rabinovici, Gil, Chai, Xiyun, Blennow, Kaj, Dage, Jeffrey L., Stomrud, Erik, Smith, Ruben, Palmqvist, Sebastian, Hansson, Oskar
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159908/
https://ncbi.nlm.nih.gov/pubmed/32426454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz2387
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