Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads to a strong impairment of the lysosomal-autophagy machinery. In mice and hu...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Autophagy
Asıl Yazarlar: Marques, André R. A., Di Spiezio, Alessandro, Thießen, Niklas, Schmidt, Lina, Grötzinger, Joachim, Lüllmann-Rauch, Renate, Damme, Markus, Storck, Steffen E., Pietrzik, Claus U., Fogh, Jens, Bär, Julia, Mikhaylova, Marina, Glatzel, Markus, Bassal, Mahmoud, Bartsch, Udo, Saftig, Paul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis 2019
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158922/
https://ncbi.nlm.nih.gov/pubmed/31282275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1637200
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