Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins

Hemagglutinins (HAs) from human influenza viruses adapt to bind α2-6-linked sialosides, overcoming a receptor-defined species barrier distinct from the α2-3 specificity of avian virus progenitors. Additionally, human-adapted HAs gain glycosylation sites over time, although their biological function...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Thompson, Andrew J., Cao, Liwei, Ma, Yuanhui, Wang, Xiaoning, Diedrich, Jolene K., Kikuchi, Chika, Willis, Shelby, Worth, Charli, McBride, Ryan, Yates, John R., Paulson, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158820/
https://ncbi.nlm.nih.gov/pubmed/32298658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.03.009
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