HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53

BACKGROUND: Diffuse midline glioma (DMG) is a pediatric malignancy with poor prognosis. Most children die less than one year after diagnosis. Recently, mutations in histone H3 have been identified and are believed to be oncogenic drivers. Targeting this epigenetic abnormality using histone deacetyla...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Capdevielle, Caroline, Desplat, Angélique, Charpentier, Justine, Sagliocco, Francis, Thiebaud, Pierre, Thézé, Nadine, Fédou, Sandrine, Hooks, Katarzyna B, Silvestri, Romano, Guyonnet-Duperat, Veronique, Petrel, Melina, Raymond, Anne-Aurélie, Dupuy, Jean-William, Grosset, Christophe F, Hagedorn, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Pediatric Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158654/
https://ncbi.nlm.nih.gov/pubmed/31711240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz215
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