Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease

Proteolytic fragmentation of polyglutamine-expanded ataxin-3 is a concomitant and modifier of the molecular pathogenesis of Machado–Joseph disease (MJD), the most common autosomal dominant cerebellar ataxia. Calpains, a group of calcium-dependent cysteine proteases, are important mediators of ataxin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Hum Mol Genet
Autores principales: Weber, Jonasz J, Haas, Eva, Maringer, Yacine, Hauser, Stefan, Casadei, Nicolas L P, Chishti, Athar H, Riess, Olaf, Hübener-Schmid, Jeannette
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
General Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158375/
https://ncbi.nlm.nih.gov/pubmed/31960910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa010
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares