Evaluating the Role of Solubility in Oral Absorption of Poorly Water‐Soluble Drugs Using Physiologically‐Based Pharmacokinetic Modeling

Poor aqueous solubility and dissolution of drug candidates drive key decisions on lead series optimization during drug discovery, on formulation optimization, and clinical studies planning during drug development. The interpretation of the in vivo relevance of early pharmaceutical profiling is often...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Clin Pharmacol Ther
Main Authors: Fink, Christina, Sun, Dajun, Wagner, Knut, Schneider, Melanie, Bauer, Holger, Dolgos, Hugues, Mäder, Karsten, Peters, Sheila‐Annie
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158207/
https://ncbi.nlm.nih.gov/pubmed/31608434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1672
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker