TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection

BACKGROUND: A craniotomy is required to access the brain for tumor resection or epilepsy treatment, and despite precautionary measures, infectious complications occur at a frequency of 1–3%. Approximately half of craniotomy infections are caused by Staphylococcus aureus (S. aureus) that forms a biof...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Aldrich, Amy L., Heim, Cortney E., Shi, Wen, Fallet, Rachel W., Duan, Bin, Kielian, Tammy
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158029/
https://ncbi.nlm.nih.gov/pubmed/32290861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01793-6
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