Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

Porcine reproductive and respiratory syndrome (PRRS) is an emerged disease of swine characterized by negligible response of type I IFNs and viral persistence. We show that the PRRSV non-structural protein 1 (Nsp1) is the viral component responsible for modulation of IFN response. Nsp1 blocked dsRNA-...

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Publicado no:Virology
Main Authors: Kim, Oekyung, Sun, Yan, Lai, Frances W., Song, Cheng, Yoo, Dongwan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157927/
https://ncbi.nlm.nih.gov/pubmed/20416917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.03.039
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