Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca(V)3.1 as the Cell Surface Receptor

Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca(2+) channel Ca(V)3.1 as the DNT receptor by CRISPR-Cas9-based genome-wide scree...

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Publicat a:mBio
Autors principals: Teruya, Shihono, Hiramatsu, Yukihiro, Nakamura, Keiji, Fukui-Miyazaki, Aya, Tsukamoto, Kentaro, Shinoda, Noriko, Motooka, Daisuke, Nakamura, Shota, Ishigaki, Keisuke, Shinzawa, Naoaki, Nishida, Takashi, Sugihara, Fuminori, Maeda, Yusuke, Horiguchi, Yasuhiko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157530/
https://ncbi.nlm.nih.gov/pubmed/32209694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03146-19
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