Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses Ca(V)3.1 as the Cell Surface Receptor

Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordetella pertussis, but its role in pertussis, B. pertussis infection, remains unknown. In this study, we identified the T-type voltage-gated Ca(2+) channel Ca(V)3.1 as the DNT receptor by CRISPR-Cas9-based genome-wide scree...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Teruya, Shihono, Hiramatsu, Yukihiro, Nakamura, Keiji, Fukui-Miyazaki, Aya, Tsukamoto, Kentaro, Shinoda, Noriko, Motooka, Daisuke, Nakamura, Shota, Ishigaki, Keisuke, Shinzawa, Naoaki, Nishida, Takashi, Sugihara, Fuminori, Maeda, Yusuke, Horiguchi, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157530/
https://ncbi.nlm.nih.gov/pubmed/32209694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03146-19
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