Transcriptomic Profiling of Tumor-Infiltrating CD4(+)TIM-3(+) T Cells Reveals Their Suppressive, Exhausted, and Metastatic Characteristics in Colorectal Cancer Patients

T cell immunoglobulin mucin-3 (TIM-3) is an immune checkpoint identified as one of the key players in regulating T-cell responses. Studies have shown that TIM-3 is upregulated in the tumor microenvironment (TME). However, the precise role of TIM-3 in colorectal cancer (CRC) TME is yet to be elucidat...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Sasidharan Nair, Varun, M Toor, Salman, Z Taha, Rowaida, Ahmed, Ayman A, Kurer, Mohamed A, Murshed, Khaled, Soofi, Madiha E, Ouararhni, Khalid, M. Alajez, Nehad, Abu Nada, Mohamed, Elkord, Eyad
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7157206/
https://ncbi.nlm.nih.gov/pubmed/32041340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines8010071
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