Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection

Female children and adults typically generate more efficacious immune responses to vaccines and infections than age-matched males, but also suffer greater immunopathology and autoimmune disease. We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South Africa,...

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Publicado en:Nat Commun
Main Authors: Adland, Emily, Millar, Jane, Bengu, Nomonde, Muenchhoff, Maximilian, Fillis, Rowena, Sprenger, Kenneth, Ntlantsana, Vuyokasi, Roider, Julia, Vieira, Vinicius, Govender, Katya, Adamson, John, Nxele, Nelisiwe, Ochsenbauer, Christina, Kappes, John, Mori, Luisa, van Lobenstein, Jeroen, Graza, Yeney, Chinniah, Kogielambal, Kapongo, Constant, Bhoola, Roopesh, Krishna, Malini, Matthews, Philippa C., Poderos, Ruth Penya, Lluch, Marta Colomer, Puertas, Maria C., Prado, Julia G., McKerrow, Neil, Archary, Moherndran, Ndung’u, Thumbi, Groll, Andreas, Jooste, Pieter, Martinez-Picado, Javier, Altfeld, Marcus, Goulder, Philip
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156749/
https://ncbi.nlm.nih.gov/pubmed/32286302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15632-y
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