Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

In amyotrophic lateral sclerosis (ALS), immune cells and glia contribute to motor neuron (MN) degeneration. We report the presence of NK cells in post-mortem ALS motor cortex and spinal cord tissues, and the expression of NKG2D ligands on MNs. Using a mouse model of familial-ALS, hSOD1(G93A), we dem...

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Udgivet i:Nat Commun
Main Authors: Garofalo, Stefano, Cocozza, Germana, Porzia, Alessandra, Inghilleri, Maurizio, Raspa, Marcello, Scavizzi, Ferdinando, Aronica, Eleonora, Bernardini, Giovanni, Peng, Ling, Ransohoff, Richard M., Santoni, Angela, Limatola, Cristina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156729/
https://ncbi.nlm.nih.gov/pubmed/32286313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15644-8
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