Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

Inflammatory bowel disease patients have a greatly increased risk of developing colitis-associated colon cancer (CAC); however, the basis for inflammation-induced genetic damage requisite for neoplasia is unclear. Using three models of CAC, we find that sustained inflammation triggers 8-oxoguanine D...

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Udgivet i:Nat Commun
Main Authors: Irrazabal, Thergiory, Thakur, Bhupesh K., Kang, Mingsong, Malaise, Yann, Streutker, Catherine, Wong, Erin O. Y., Copeland, Julia, Gryfe, Robert, Guttman, David S., Navarre, William W., Martin, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156452/
https://ncbi.nlm.nih.gov/pubmed/32286276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15549-6
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