Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2

Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and ubiquitylation. Although binding between those proteins has been investigated, a comparative study of all human 14-3-3 isoforms interacting with...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Manschwetus, Jascha T., Wallbott, Maximilian, Fachinger, Alexandra, Obergruber, Claudia, Pautz, Sabine, Bertinetti, Daniela, Schmidt, Sven H., Herberg, Friedrich W.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155755/
https://ncbi.nlm.nih.gov/pubmed/32317922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00302
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