Image‐Based Morphological Profiling Identifies a Lysosomotropic, Iron‐Sequestering Autophagy Inhibitor

Chemical proteomics is widely applied in small‐molecule target identification. However, in general it does not identify non‐protein small‐molecule targets, and thus, alternative methods for target identification are in high demand. We report the discovery of the autophagy inhibitor autoquin and the...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Laraia, Luca, Garivet, Guillaume, Foley, Daniel J., Kaiser, Nadine, Müller, Sebastian, Zinken, Sarah, Pinkert, Thomas, Wilke, Julian, Corkery, Dale, Pahl, Axel, Sievers, Sonja, Janning, Petra, Arenz, Christoph, Wu, Yaowen, Rodriguez, Raphaël, Waldmann, Herbert
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154763/
https://ncbi.nlm.nih.gov/pubmed/31769920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913712
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