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Development of a PDEδ‐Targeting PROTACs that Impair Lipid Metabolism
The prenyl‐protein chaperone PDEδ modulates the localization of lipidated proteins in the cell, but current knowledge about its biological function is limited. Small‐molecule inhibitors that target the PDEδ prenyl‐binding site have proven invaluable in the analysis of biological processes mediated b...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7154537/ https://ncbi.nlm.nih.gov/pubmed/31829492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913904 |
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