M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations

BACKGROUND: Macrophages (Mф) can be M1/M2 polarized by Th1/2 signals, respectively. M2-like Mф are thought to be important in asthma pathogenesis, and M1-like in anti-infective immunity, however their roles in virus-induced asthma exacerbations are unknown. Our objectives were (i) to assess polarise...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Nikonova, Alexandra, Khaitov, Musa, Jackson, David J., Traub, Stephanie, Trujillo-Torralbo, Maria-Belen, Kudlay, Dmitriy A., Dvornikov, Anton S., del-Rosario, Ajerico, Valenta, Rudolf, Stanciu, Luminita A., Khaitov, Rahim, Johnston, Sebastian L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152663/
https://ncbi.nlm.nih.gov/pubmed/32279057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102734
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