Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis

Three-dimensional (3D) cell culture is well documented to regain intrinsic metabolic properties and to better mimic the in vivo situation than two-dimensional (2D) cell culture. Particularly, proline metabolism is critical for tumorigenesis since pyrroline-5-carboxylate (P5C) reductase (PYCR/P5CR) i...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Choi, Un Yung, Lee, Jae Jin, Park, Angela, Zhu, Wei, Lee, Hye-Ra, Choi, Youn Jung, Yoo, Ji-Seung, Yu, Claire, Feng, Pinghui, Gao, Shou-Jiang, Chen, Shaochen, Eoh, Hyungjin, Jung, Jae U.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7149499/
https://ncbi.nlm.nih.gov/pubmed/32213586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918607117
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