Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, which is very difficult to treat and commonly develops resistance to chemotherapy. The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision rep...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Xin, Xing, Wen, Ti, Gong, Li-Bao, Deng, Ming-Ming, Hou, Ke-Zuo, Xu, Lu, Shi, Sha, Qu, Xiu-Juan, Liu, Yun-Peng, Che, Xiao-Fang, Teng, Yue-E
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147381/
https://ncbi.nlm.nih.gov/pubmed/32318339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00425
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