FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple...

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Udgivet i:J Cell Biol
Main Authors: Smith, Jean A., Curry, Ennessa G., Blue, R. Eric, Roden, Christine, Dundon, Samantha E.R., Rodríguez-Vargas, Anthony, Jordan, Danielle C., Chen, Xiaomin, Lyons, Shawn M., Crutchley, John, Anderson, Paul, Horb, Marko E., Gladfelter, Amy S., Giudice, Jimena
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147106/
https://ncbi.nlm.nih.gov/pubmed/32328638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201911129
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