p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulat...

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Published in:Nat Commun
Main Authors: Deng, Longfei, Yao, Pengbo, Li, Le, Ji, Fansen, Zhao, Shuang, Xu, Chang, Lan, Xun, Jiang, Peng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145870/
https://ncbi.nlm.nih.gov/pubmed/32273511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15573-6
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