DNA barcoding reveals that injected transgenes are predominantly processed by homologous recombination in mouse zygote

Mechanisms that ensure repair of double-strand DNA breaks (DSBs) are instrumental in the integration of foreign DNA into the genome of transgenic organisms. After pronuclear microinjection, exogenous DNA is usually found as a concatemer comprising multiple co-integrated transgene copies. Here, we in...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Smirnov, Alexander, Fishman, Veniamin, Yunusova, Anastasia, Korablev, Alexey, Serova, Irina, Skryabin, Boris V, Rozhdestvensky, Timofey S, Battulin, Nariman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145541/
https://ncbi.nlm.nih.gov/pubmed/31740957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1085
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