Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses

Cyclic di-AMP (c-di-AMP) is an important signaling molecule for pneumococci, and as a uniquely prokaryotic product it can be recognized by mammalian cells as a danger signal that triggers innate immunity. Roles of c-di-AMP in directing host responses during pneumococcal infection are only beginning...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Wooten, Alicia K., Shenoy, Anukul T., Arafa, Emad I., Akiyama, Hisashi, Martin, Ian M. C., Jones, Matthew R., Quinton, Lee J., Gummuluru, Suryaram, Bai, Guangchun, Mizgerd, Joseph P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145409/
https://ncbi.nlm.nih.gov/pubmed/32300347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00554
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